Fig. 1: Two independent viral entry pathways and inhibition data of compounds against two primary host proteases. | Nature Communications

Fig. 1: Two independent viral entry pathways and inhibition data of compounds against two primary host proteases.

From: Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Fig. 1

a SARS-CoV-2 can adopt two independent cell entry pathways involving host proteases. Created with BioRender.com. b The kinetic activity of TMPRSS2, data points are shown as mean ± SD for four biological independent replicates. c–i Dose-response curves of compounds inhibiting TMPRSS2 and CTSL/CTSB, IC50 values and data points are shown as mean ± SD for four biological independent replicates.

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