Fig. 4: Heatmap of PheWAS associations for selected disease endpoints.

Each entry in the heatmap represents a possible association between a disease group (row) and a lipidome trait (column). The red color indicates that at least one variant among the lead variants or representative variants of the lipidome trait is also associated with the disease at the multiple testing-corrected threshold P < 5.24659e-11 and the lipidome trait and disease colocalize at CLPP > 0.01. Two-sided P-values for lipidome traits were calculated using a linear-mixed-model (uv) and canonical correlation analysis (mv). Two-sided P-values for disease endpoints were calculated using mixed-model logistic regression. The gray color denotes that no such association is observed. The columns are split by lipid classes. The effective sample size N_eff (see the “Methods” section) and the number of loci are given beneath each disease endpoint.