Fig. 1: DNPH1 cleaves the glycosidic bond in hmdUMP.
From: Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1
Hydrolysis generates deoxyribose monophosphate (dRP) and hydroxymethyl uracil (hmU) products. Phosphate, deoxyribose and hmU moieties are coloured orange, black and green respectively.
