Fig. 1: Tonotopic mapping of the core in awake marmosets.
From: Change detection in the primate auditory cortex through feedback of prediction error signals
a Schematic right-side view of marmoset brain (left), and an enlarged view of the auditory cortex in the superior temporal gyrus (right). AL, anterolateral belt; ML, mediolateral belt; CL, caudolateral belt; RPB, rostral parabelt; CPB, caudal parabelt. b Schematic illustration of the imaging window frame (top) and imaging system (bottom). c Schematic illustration of the experiment. d Representative epi-fluorescence image of the core in the right hemisphere. Green dots indicate AAV-injected sites. Similar images were obtained in the total 25 sessions from three animals. e Calcium response maps for five pure-tone stimuli (1, 2, 4, 8, and 16 kHz). Rightmost image, the best frequency map. Black lines indicate the outer lines of an imaging window or contours of the sub-regions of the auditory cortex that were inferred from an atlas. For each pixel of 256 × 256-pixel regions, the color of the corresponding BF and amplitude was assigned. f Top and middle, example calcium traces from two boxed regions shown in (d) (cores 1 and 2). Each color bar indicates the presentation timing of the corresponding tone stimulus. Bottom, trial-averaged response to each tone in cores 1 and 2. Responses are aligned to the tone onset. Shading on each line indicates SEM. g, h Top left, two-photon images of cores 1 (g) and 2 (h) shown in (d). Top right, maps of BF of tone-responsive neurons in cores 1 (g) and 2 (h). Bottom, trial-averaged responses of four neurons labeled in the top images. Responses are aligned to the tone onset. The type, latency, and selectivity index of the sound frequency (SI) of each neuron are also shown (see Supplementary Table 2). Shading on each line indicates SEM.
