Fig. 3: The allele-specific open chromatin (ASOC) regions in B-ALL.

a Violin plot showing the percentage of ASOC regions and biallelic open chromatin (BiOC) regions in each B-ALL sample. (32 samples, one sample per patient, p < 2.2e−16, two-sided Wilcoxon test). Box plots show the median number as centers, the upper and lower hinges represent 75th and 25th percentile, and whiskers extend to largest and smallest values no more than 1.5*IQR. b Bar plot showing the proportion of ASOC and BiOC regions that are found in different genomic regions. Data are presented as mean values ± SD. (32 samples, one sample per patient). c Scatter plot presenting the recurrent ASOCs linked to leukemia-associated SNPs. Each dot represents one ASOC-SNP pair in an individual B-ALL sample, and the size of the dot represents the number of samples carrying the ASOC-SNP. The significance of different chromatin accessibility between two alleles is shown on the y axes as −log₁₀(p value) (Methods) with dashed line represent a p value of 0.05. The difference of chromatin accessibility between two alleles is shown as absolute value on x axes, with dashed line represent a difference of 0.2 (Methods). Different SNPs are represented by different colors. (44 samples of 32 patients). d The table displays detailed information about the seven SNPs shown in (c).