Fig. 4: Methacrylate peptides bind conserved 14-3-3 lysine residue.
From: A simple method for developing lysine targeted covalent protein reagents
a Overlay of the CovPepDock prediction (Light brown) and co-crystal structure of peptide 8 (blue sticks) bound to 14-3-3σ (white surface; left), and a close-up view on the methacrylate residue (right). Final 2Fo-Fc electron density (light blue mesh, contoured at 1.0σ) is displayed for peptide 8 (right). Similarly, b docking overlay (left) and close-up view (right) of peptide 3. Final 2Fo-Fc electron density (light blue mesh, contoured at 1.0σ) is displayed for peptide 3 (right).
