Fig. 5: CamoTSS detected transcription start site switch from epithelial cells of gastric cancer. | Nature Communications

Fig. 5: CamoTSS detected transcription start site switch from epithelial cells of gastric cancer.

From: CamoTSS: analysis of alternative transcription start sites for cellular phenotypes and regulatory patterns from 5' scRNA-seq data

Fig. 5

A UMAP visualization of epithelial cells (n = 8485) in gastric cancer. Each dot represents an individual cell, where colors indicate subcell type. B Volcano plot displaying the relationship between ELBO_gain and effect size on logit(PSI) for detecting differential TSS between normal and tumor cells. Cell_coeff is the effect size on logit(PSI). A positive value means higher PSI in normal cells. ELBO_gain denotes the evidence lower bound difference for the two hypotheses (Methods). C Boxplot showing an example gene that has a significant TSS usage between normal (n = 5977) and tumor cells (n = 2508). D Genome track plot of SLC29A1 in normal and tumor cells. One horizontal genome track represents the coverage of all cells within one specific cell type. E Bar plot exhibiting the enriched terms of genes with differential TSS usage between normal and tumor epithelial cells in gastric cancer. Source data are provided as a Source Data file. F Scatter plot of the binding frequency of human TFs from JASPAR database on 453 TSS regions elevated in normal and tumor epithelial cells. Source data are provided as a Source Data file.

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