Fig. 4: Application of the present method to the synthesis of oligonucleotides.

A Derivatization of (R_P)/(S_P)-3aa to give the phosphoramidites (R_P)/(S_P)-3aa-3. B Solid-supported automated synthesis of oligonucleotides. The synthesis of Oligo-1 was exemplified. C Retention times obtained from liquid chromatography analysis of synthesized oligonucleotides.