Nature Communications

Table 1 Screening of leaving groups^a

From: Synthesis of tertiary alkylphosphonate oligonucleotides through light-driven radical-polar crossover reactions


Entry	Phosphite substrate	Yield (%) of 3aa^b
1	1a-1: R¹ = Ph, R² = H	71
2^c	1a-1: R¹ = Ph, R² = H	20
3	1a-2: R¹, R² = Me	68
4	1a-3: R¹ = Me, R² = H	trace
5	1a-4: R¹, R² = H	trace

^a Each reaction was carried out with 1 (0.05 mmol), 2a (0.15 mmol), PTH1 (0.05 mmol) and LiBF₄ (0.05 mmol) in MeCN (0.3 mL) and DCM (0.2 mL) at 10 °C under blue LED irradiation for 18 h^{b 1}.H NMR yields^c.PTH1 (10 mol%) was used.

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