Fig. 1: Summary of nonviral delivery systems for primary T lymphocyte delivery.
From: Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism
a Representative nonviral delivery systems for primary T-cell transfection. b CART/mRNA complexes and their pH-driven nitrogen-to-oxygen acyl shift triggering charge cancellation and mRNA release. c bAC CARTs possess a polymeric backbone with distinct lipid spacing, leading to improved T-cell delivery.
