Fig. 6: Identified MS proteins share functional context. | Nature Communications

Fig. 6: Identified MS proteins share functional context.

From: Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis

Fig. 6

a An MS network was formed by connecting the proteins in the normalized age-related MS score (nARMSS) model (black star) and the differentially expressed proteins (DEPs) that overlapped in the discovery and the replication cohort (yellow star). The proteins were connected using STRING (combined interaction score > 0.4) with one intermediate protein allowed to be added to connect proteins. The proteins are color-coded on the log2 fold change (FC), comparing persons with MS with healthy controls. The white colored proteins were not included in the proteomics profiling. IL-12p35 was not measured in the proteomics profiling but is included as a DEP as it together with IL-12p40 represents IL-12p70. The linewidth of the interactions is related to the combined interaction score of each interaction in STRING. b Proteins in the MS network divided into functional categories. The proteins were categorized into groups with shared functionality based on Gene Ontology enrichment analyses (red), and the literature (black).

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