Fig. 7: Tonic nRE stimulation started during the prodromal disease stage prevents later impairments of spatial working memory in fAD mice. | Nature Communications

Fig. 7: Tonic nRE stimulation started during the prodromal disease stage prevents later impairments of spatial working memory in fAD mice.

From: Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model

Fig. 7

a Experimental design: SWM test- spatial working memory test via delta maze. GA: 3 h of 1.5% isoflurane. Ephys – LFP recording and IES analysis at age 4–5 months, after the first DBS. b, c Impairments of SWM in old (8–9-months APP/PS1 mice: -DBS old) compared to young (4–5-months. AP/PS1 mice: -DBS young) in the delta maze was prevented by tDBS-nRE (+DBS old). One-way ANOVA with Sidak’s multiple comparison tests: 60 sec delay: -DBS old vs +DBS old: P = 0.024, -DBS old vs -DBS young: P = 0.002; n = 7 per group old (5 males, 2 females) and n = 8 young (males). 90 s delay: -DBS old vs +DBS old: P = 0.018, -DBS old vs -DBS young: P = 0.0013. d Frequency of CA1-IES during GA in APP/PS1 mice at young age inversely correlates to spatial working memory performance at the 60 seconds delay (Spearman r = −0.65, P = 0.0198) and 90 s delay (Spearman r = −0.76, P = 0.0035) of the same mice at old age. Error bars represent SEM; ns non-significant, *P < 0.05, **P < 0.01.

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