Fig. 2: FSH, independent of estrogen, regulates GSIS via FSHR.
From: Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
a Schematic of Fshr+/+ (WT) and Fshr−/− (KO) female mice subjected to different treatments. b Serum FSH and E2 levels in WT, KO and KO + E2 female mice with E2 supplement. nWT = 10, nKO = 9, nKO+E2 = 10. **P < 0.01 vs. WT, ##P < 0.01 vs. KO + E2. c Glucose tolerance test and AUC of female mice in different treatment groups. nWT = 10, nKO = 9, nKO+E2 = 10. *P < 0.05 vs. WT, **P < 0.01 vs. WT, ##P < 0.01 vs. KO + E2. d Insulin tolerance test and AUC of female mice in different treatment groups. nWT = 10, nKO = 9, nKO+E2 = 10. e Blood insulin levels at 0 min and 30 min after glucose injection and its fold changes of female mice with different treatments. nWT = 10, nKO = 9, nKO+E2 = 10. **P < 0.01 vs. WT. All the WT, KO and KO + E2 mice were performed the serum and metabolic tests at 10 weeks of age. f Glucose tolerance test and AUC of Ctrl (Fshrf/f) and CKO (Fshrf/f; Pdx1-Cre) female mice. nCtrl = 9, nCKO = 8. *P < 0.05, **P < 0.01. g Insulin tolerance test and AUC of Ctrl and CKO female mice. nCtrl = 9, nCKO = 8. h Blood insulin levels at 0 min and 30 min after glucose injection and its fold changes of Ctrl and CKO female mice. nCtrl = 9, nCKO = 8. **P < 0.01. All the Ctrl and CKO mice were performed the serum and metabolic tests at 8 weeks of age. Data (b–h) were shown as mean ± s.e.m. and analyzed by one-way ANOVA (b–e) or unpaired two-tailed Student’s t-tests (f–h). Statistical details are in Supplementary Table 2. Source data are provided as a Source data file.
