Fig. 4: High circulating levels of FSH impaired glucose tolerance and insulin secretion.
From: Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
a Schematic of C57BL/6 female mice receiving different treatments. b Serum FSH and serum E2 levels in female mice with different treatments. nSham = 7, nOGF = 8, nOGFE = 7. **P < 0.01 vs. Sham, ##P < 0.01 vs. OGFE. c Glucose tolerance test and AUC of female mice in each group. nSham = 7, nOGF = 8, nOGFE = 6. *P < 0.05 vs. Sham, **P < 0.01 vs. Sham, #P < 0.05 vs. OGFE. d Insulin tolerance test and AUC in female mice with different treatments. nSham = 7, nOGF = 7, nOGFE = 6. e Blood insulin levels at 0 min and 30 min after glucose injection and its fold changes of female mice with different treatments. n = 7 per group, **P < 0.01 vs. Sham, #P < 0.05 vs. OGFE. All the female mice were performed the serum and metabolic tests at 13 weeks of age. Data (b–e) were shown as mean ± s.e.m. and analyzed by one-way ANOVA. Statistical details are in Supplementary Table 2. Source data are provided as a Source data file.
