Fig. 3: Substrate scope for the atroposelective formal C–C bond insertion.
From: Asymmetric formal C–C bond insertion into aldehydes via copper-catalyzed diyne cyclization
Reaction conditions: 4 (0.1 mmol), 2 (0.2 mmol), Cu(CH3CN)4PF6 (0.01 mmol), L4 (0.012 mmol), NaBArF4 (0.012 mmol), DCE (2 mL), 0 °C, N2, 10–120 h, in Schlenk tubes; yields were those for the isolated products; ees were determined by HPLC analysis. a20 °C. bL3 was used instead of L4. c25 °C. d−10 °C. Cyp = cyclopentyl.
