Fig. 3: ATP8B1 autoinhibition mechanism and lipid groove opening.
From: Activation and substrate specificity of the human P4-ATPase ATP8B1
Close-up view of the cytosolic domains with the ATP8B1 N- and C-terminal tails shown with their associated cryo-EM density when present (top row, contour map: 4.17σ and 5.47σ for the E2Pautohinhibited “closed” and “open” conformations, respectively) and the lipid-binding site in cartoon representation (middle row) or as electrostatic surface (bottom row) in the different E2 conformations. Color code as in Fig. 1, with the N-terminal tail of ATP8B1 colored in light blue.
