Fig. 3: Diminished motor preparatory activity in the auditory cortex of Df(16)A+/− mice. | Nature Communications

Fig. 3: Diminished motor preparatory activity in the auditory cortex of Df(16)A+/− mice.

From: Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition

Fig. 3

a Raster plot (top) and peri-stimulus time histogram (bottom) showing the firing rate of an example neuron preceding a lever press. b Changes in firing rates during the time period preceding lever press (relative to average firing rates 900–1000 ms prior to lever press) in the two genotypes. Asterisks indicate timepoints where firing rates differed significantly between genotypes (p < 0.01, two-sided Wilcoxon rank-sum test). c Average change in firing rates 0–200 ms before lever press in each neuron from the two genotypes. Ten neurons are not visible due to the scale of the y-axis. Horizontal black lines indicate the mean of each genotype. P value was calculated using a two-sided Wilcoxon rank-sum test. Shaded areas indicate mean ± s.e.m. across trials (a) or neurons (b). Data in (b–d) represent 183 neurons from 9 Df(16)A+/− mice and 189 neurons from 9 wild-type mice. Source data are provided as a Source Data file.

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