Fig. 6: Drug target analysis. | Nature Communications

Fig. 6: Drug target analysis.

From: Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases

Fig. 6: Drug target analysis.The alternative text for this image may have been generated using AI.

Enrichment of drug targets and druggability in Mendelian disorder genes and indicated candidate gene sets. DT: OR of known drug targets. xDC: Ratio of median number of drug-gene interactions per candidate gene to the median of non-candidates, only genes with drug-gene interactions are considered. Ratios with FDR > 0.05 (U-test) are grayed out. Dr: OR of druggable genes. Dr-: OR of druggable genes, after all drug targets have been removed. Odds Ratios with FDR > 0.05 (Fisher’s exact test) are grayed out. For all panels, precise P values, FDR, and n for each test are shown in Supplementary Data 22.

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