Fig. 8: Summary of Results. | Nature Communications

Fig. 8: Summary of Results.

From: Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Fig. 8: Summary of Results.The alternative text for this image may have been generated using AI.

Under oxidative stress reduced BMPR2 causes a reduction in FOXF1 as well as P53 and ATM, all required for DNA repair. FOXF1 is also required to transcribe angiogenesis genes to regenerate damaged endothelium. Thus reduced FOXF1 leads to PAH. Foxf1 delivery by AAV in a mouse with Bmpr2 deleted in endothelium is sufficient to restore P53 and ATM to repair DNA damage and transcribe angiogenesis genes required to reverse persistent PAH. Created with BioRender.com.

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