Fig. 4: D-RAWs for the treatment of epidermal bacterial infection in immunodeficient mice.
From: Adoptive macrophage directed photodynamic therapy of multidrug-resistant bacterial infection
a Schematic illustration of the construction of epidermal bacterial infection in immunodeficient mice and the therapy routine based on D-RAWs (C57BL/6 mice were i.p. injected with cyclophosphamide at a dosage of 100 mg kg−1 for three consecutive days before bacterial infection.) (Created with BioRender.com). b Fluorescence images of infected mice post injecting D-RAWs or Lyso700D. c Bacterial burden in the infection sites and blood at 36 h and 50 h post phototherapy. d The survival rate of mice with epidermal bacterial infection post phototherapy. e–g The BWs (e), WBCs (f), and LYMs (g) of mice. Data in b and c are from n = 3 biologically independent samples. Data in d and e are from n = 10 biologically independent samples. Data in f and g are from n = 5 biologically independent samples. All data in b–g are presented as mean ± SD. Statistical analysis was performed by a two-tailed unpaired t-test (f, g). ns no significant difference; *P < 0.05; **P < 0.01; ***P < 0.001. d, e Share a set of color codes. PBS (blue); PBS + RAWs (green); D (light) (gray); D + RAWs (i.v.) (pink); D + RAWs (i.v. + i.p.) (orange). ND not detected, ns non-significant.
