Table 2 Summary of multivariable logistic regression models evaluating relationship between each chorioretinal metric (total macular volume and choroidal thickness [locations I, II and III]) and the primary outcomes of a decline in eGFR of ≥10 at 1 year and ≥20% at 2 years

	Standard error	z-value	OR	Lower 95% CI	Upper 95% CI	p	Residual deviance
Decline in eGFR of ≥10% at 1 year
Total macular volume (per 1 mm³ decrease)	0.424	−2.08	2.42	1.07	5.70	0.041	240 on 195 df
Choroid (location I) (per 10 μm decrease)	0.002	−0.30	1.01	0.97	1.05	0.763	244 on 195 df
Choroid (location II) (per 10 μm decrease)	0.002	−0.99	1.02	0.98	1.06	0.326	243 on 195 df
Choroid (location III) (per 10 μm decrease)	0.002	−2.38	1.06	1.01	1.11	0.026	238 on 195 df
Decline in eGFR of ≥20% at 2 years
Total macular volume (per 1 mm³ decrease)	0.492	−1.79	2.42	0.94	6.57	0.071	175 on 150 df
Choroid (location I) (per 10 μm decrease)	0.002	−0.22	1.01	0.96	1.05	0.821	177 on 149 df
Choroid (location II) (per 10 μm decrease)	0.002	0.38	0.99	0.95	1.04	0.705	177 on 149 df
Choroid (location III) (per 10 μm decrease)	0.003	−1.32	1.04	0.98	1.09	0.198	175 on 149 df

Two sided analyses. Models were adjusted for patient age, sex, and baseline renal function, systolic blood pressure and urinary PCR.
CI confidence interval, df degrees of freedom, eGFR estimated glomerular filtration rate, OR odds ratio.

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