Fig. 6: ICMS-evoked activity depends on behavior. | Nature Communications

Fig. 6: ICMS-evoked activity depends on behavior.

From: Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex

Fig. 6

a Top: Squeeze, grasp, and transport in the VR environment. Bottom: Three example motor channels from Participant C1 exhibit different responses to four levels of ICMS across three motor conditions (squeeze, grasp, transport). Traces denote the firing rate evoked by stimulation at the four levels after subtraction of the mean across conditions. b Stimulation amplitude classifier performance. Classifiers were trained from M1 activity on one of the three conditions and tested on activity in each condition (cross-validated within condition). c Task dependence—gauged by the strength of the condition/amplitude interaction divided by the strength of the main effect of amplitude—is nearly zero for the pulse-locked responses (direct) but varies widely for the non-pulse locked (indirect) ones. The units with direct input from somatosensory cortex respond the same way to ICMS across behavioral conditions.

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