Fig. 7: Context-dependent modulation effects of vLGN input.

a Schematic of SC recording responding to moving dots over low- (left) or high-SF (right) grating background. b Size tuning of an example SC neuron under low- (solid line and black dots) or high-SF (dash line and hollow dots) background. n = 20 trials. c Optimal size in high-SF (HSF) vs. low-SF (LSF) background. d Comparison of optimal sizes between the two background conditions. n = 64 neurons, ****p < 1.0 × 10⁻¹⁵, two-tailed Wilcoxon matched-pairs signed rank test. Black line and bar represent mean ± s.e.m. e Schematic of SC recording with photo-inhibition of vLGN VGAT+ neurons. f Optimal size in LED-ON vs. LED-OFF condition with low-SF background. Inset, fold change of optimal size. n = 44 neurons, ****p = 7.3 × 10⁻¹¹, two-tailed Wilcoxon matched-pairs signed rank test. g Similar to (f) but for high-SF background. n = 44 neurons, **p = 0.0041, two-tailed Wilcoxon matched-pairs signed rank test. h Optimal size in high- vs. low-SF background in the LED-OFF (gray) or LED-ON (orange) condition. i Comparison of optimal sizes between two SF backgrounds in LED-OFF and LED-ON conditions. n = 44 neurons, ****p = 2.9 × 10⁻¹⁰; n.s., p = 0.6694, two-tailed Wilcoxon matched-pairs signed rank test. Data are presented as mean ± s.e.m. in (b, d, f, g and i). Source data are provided as a Source Data file.