Fig. 1: The L-malate-rich large intestine is the predominant site of EHEC O157:H7 colonization in infant rabbits. | Nature Communications

Fig. 1: The L-malate-rich large intestine is the predominant site of EHEC O157:H7 colonization in infant rabbits.

From: Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization

Fig. 1: The L-malate-rich large intestine is the predominant site of EHEC O157:H7 colonization in infant rabbits.The alternative text for this image may have been generated using AI.

a Bacterial counts of wild-type EHEC O157:H7 (abbreviated as O157 WT in all figures) recovered from the ileum and colon of infant rabbits at 1-7 d post-infection. b Relative abundance of metabolites that were differentially abundant in the colon versus that in the ileum (blue and red: higher levels in ileal and colonic contents, respectively). Boxes represent the interquartile range, with the vertical line representing the median value. Error bars represent maximum and minimum values (n = 4 biologically independent samples). c Quantification of L-malate concentrations in the colonic contents obtained from conventional and antibiotic-treated infant rabbits. For (a, c), the horizontal lines represent the geometric means. n = 7 infant rabbits per group were used. Statistical significance was assessed via the two-sided Mann‒Whitney rank-sum test. Source data are included in Source Data file.

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