Fig. 5: n-BANKs stabilized the vessel-like structures and built functional pericyte-endothelial cell tubes. | Nature Communications

Fig. 5: n-BANKs stabilized the vessel-like structures and built functional pericyte-endothelial cell tubes.

From: Enhanced pericyte-endothelial interactions through NO-boosted extracellular vesicles drive revascularization in a mouse model of ischemic injury

Fig. 5: n-BANKs stabilized the vessel-like structures and built functional pericyte-endothelial cell tubes.The alternative text for this image may have been generated using AI.

A Representative images and quantitative assessment of pericyte recruitment by Matrigel angiogenesis assays at 5 h after endothelial tube formation, which was 9 h after treatment (n = 3; Model, ****P < 0.0001; GTN, ***P = 0.0001; n-BANK, n.s. = 0.0586). Pericytes were labeled with DiI (red) and SVEC cells were stained with Calcein-AM (green). Scale bar, 500 μm. B Evaluation of functional blood vessel formation by collagen gel contraction assays. C Quantification of collagen contraction between pericytes and endothelial cells (n = 4; GTN, **P = 0.0012; n-BANK, ****P < 0.0001). D Diagram illustrating recruitment of pericytes to vascular endothelium by n-BANKs. Data are mean ± SD, ** is P < 0.01, *** is P < 0.001, **** is P < 0.0001, n.s. is P > 0.05 by one-way or two-way ANOVA test.

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