Fig. 7: The effect of complete revascularization to normalize blood flow in the ischemic areas. | Nature Communications

Fig. 7: The effect of complete revascularization to normalize blood flow in the ischemic areas.

From: Enhanced pericyte-endothelial interactions through NO-boosted extracellular vesicles drive revascularization in a mouse model of ischemic injury

Fig. 7: The effect of complete revascularization to normalize blood flow in the ischemic areas.The alternative text for this image may have been generated using AI.

A Photographs showing new vessel formation across ligation sites of the ischemic hindlimbs at day 3 after treatment. Mice underwent femoral artery ligation to induce hindlimb ischemia. B Representative images and quantitative assessment of blood flow after hindlimb ischemia by laser Doppler at indicated day (n = 50; Day 3: Model versus EVs ***P = 0.0005, Model versus GTN ***P = 0.0007, Model versus n-BANK ***P = 0.0002, Model versus 10% n-BANK ***P = 0.0003; Day 7: GTN versus n-BANK **P = 0.0017, GTN versus 10% n-BANK ****P < 0.0001; Day 14: ****P < 0.0001). C Time course of blood flow recovery by laser Doppler imaging in hindlimb of mice treated with different formulations. Data are mean ± SD, ** is P < 0.01, *** is P < 0.001, **** is P < 0.0001 by one-way ANOVA test.

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