Fig. 8: n-BANKs improved limb salvage following severe ischemic injury. | Nature Communications

Fig. 8: n-BANKs improved limb salvage following severe ischemic injury.

From: Enhanced pericyte-endothelial interactions through NO-boosted extracellular vesicles drive revascularization in a mouse model of ischemic injury

Fig. 8: n-BANKs improved limb salvage following severe ischemic injury.The alternative text for this image may have been generated using AI.

A Representative serial photographs of ischemic hindlimbs at days 0, 3, 7, and 14 after treatment. B Limb salvage rate and (C) tissue salvage sore of ischemic hindlimbs in different treatment groups (n = 4; n-BANK versus Model ***P = 0.0004, n-BANK versus EVs ***P = 0.0004, n-BANK versus GTN **P = 0.0094). D Different genes related to collateral artery remodeling on thigh adductor muscle and (E) different blood flow recovery related genes on gastrocnemius muscle harvested from ischemic hindlimbs at day 3 (n = 3; CXCL10: Model versus EVs *P = 0.0419, Model versus GTN *P = 0.0410, Model versus n-BANK ****P < 0.0001, Model versus 10% n-BANK ***P = 0.0006; CXCL2: ****P < 0.0001; CCL2: Model versus EVs *P = 0.0400, Model versus GTN *P = 0.0384, Model versus n-BANK ****P < 0.0001, Model versus 10% n-BANK ***P = 0.0008; Vegfα: *P = 0.0181; Pdgfb: **P = 0.0014; Pgf: ****P < 0.0001). F Masson’s trichrome staining of histological ischemic hindlimb sections at day 3 after surgery (n = 3). G Masson’s trichrome staining of muscle sections from healthy mice and n-BANK treated mice at day 14 after surgery. Light blue staining for collagen indicates fibrosis, and muscle fibers are stained red (n = 3). Scale bar, 1000 μm. Data are mean ± SD, * is P < 0.05, ** is P < 0.01, *** is P < 0.001, **** is P < 0.0001 by one-way ANOVA test.

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