Fig. 2: Substrate scope and gram-scale reactions. | Nature Communications

Fig. 2: Substrate scope and gram-scale reactions.

From: Facile access to benzofuran derivatives through radical reactions with heteroatom-centered super-electron-donors

Fig. 2

a Scope of the 2-Iodophenyl Allenyl Ethers 1. b Application of the Thiols 4 in the radical coupling reaction. c Application of the anilines 6 in the radical coupling reaction. d Gram-scale radical reactions. aReaction conditions as stated in Table 1, entry 11. Yields are isolated yields after purification by column chromatography. bLiHMDS (0.20 mmol) was used instead of the LDA under otherwise identical conditions to Table 1, entry 11. cUnless otherwise specified, the reactions were carried out using 1a (0.15 mmol), 4 (0.10 mmol), LiHMDS (0.20 mmol), DME (2.0 mL) at 50 °C for 12 h under N2. Yields are isolated yields after purification by column chromatography. dThe yield of 5a did not change when carrying out the reaction in dark condition. eUnless otherwise specified, the reactions were carried out using 1a (0.10 mmol), 6 (0.10 mmol), LDA (0.20 mmol), DME (2.0 mL) at 50 °C for 24 h under N2. Yields are isolated yields after purification by column chromatography.

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