Fig. 3: Screened chiral ligands.
Reaction conditions: 1a (0.1 mmol), 2a (0.2 mmol), NaOtBu (4 equiv.), H2O (2 equiv.), [Pd(allyl)Cl]2 (2.5 mol%), Xu8 (10 mol%) in 1 mL Et2O/Hexane under N2 at RT for 72 h. Isolated yields. ee was determined by chiral HPLC analysis.
