Fig. 5: The brain and ileum share a cluster of migrating CD11c+ cells.
From: Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease
a Dotplot of selected microglia marker genes. b Violin plot of Ptprc (CD45) expression in the different CD11c+ clusters. c Network plot of the top 120 upregulated GO terms in the Macrophage 1 cluster. Migration related terms are bolded. Enrichment was determined using a one-sided hypergeometric test and the Benjamini–Hochberg correction for multiple comparisons. d Heatmap of the genes in the Leukocyte Migration GO term. e Representative IHC of LRP1 and HA in the distal ileum of hαSyn mice five weeks post-OP (n = 3 mice). Scale bars represent 50 μm in the larger images and 10 μm in the inserts.
