Fig. 1: Global-to-local genome-wide association study of cranial vault shape.
From: Joint multi-ancestry and admixed GWAS reveals the complex genetics behind human cranial vault shape
a Hierarchical segmentation of cranial vault shape resulting in 15 cranial vault segments (cyan) across 4 hierarchical levels. b Manhattan plot of genome-wide associations. For each SNP the lowest P-value (CCA, upper-tail chi squared) across all 15 cranial vault segments was plotted. Full and dashed horizontal lines represent genome-wide (P < 5e−8) and study-wide (P < 4.37e−9) significance thresholds respectively. Plausible candidate genes are annotated to each genome-wide significant locus (n = 30) (Methods). c Number of genetic loci reaching genome-wide significance (P < 5e−8; CCA, upper-tail chi squared) in each cranial vault segment.
