Fig. 4: Protein co-expression network and tumor progression landmarks. | Nature Communications

Fig. 4: Protein co-expression network and tumor progression landmarks.

From: Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

Fig. 4

a Protein co-expression network of 896 nodes and 13,574 edges. Nodes are color-coded according to module membership. Representative enriched biological terms are shown for distinct modules. b Density plots of the pairwise protein–protein correlations for the interactions shown in the network. Number of interactions in Network (n = 13,574) and number of interactions in STRING (n = 5611). Boxplots show median (central line), upper and lower quartiles (box limits), min to max range. c Aberrant protein expression levels were superimposed on the network for each histological subtype. The red and blue dots represent up- and downregulated differentially expressed proteins, respectively. d Sub-network of Module31. e Boxplots illustrated the abundances of IFIT1 (P value = 3.3e-05), IFIT2 (P value = 8.7e-04), and IFIT3 (P value = 9.5e-07) in the different histological subtypes. The P values are calculated using Kruskal–Wallis test. The asterisk character represents the significance of the expression discrepancy, ***P value < 0.001 and ****P value < 0.0001. Stage I samples (n = 81), Stage II samples (n = 47), Stage III samples (n = 88), and Stage IV samples (n = 23). Boxplots show median (central line), upper and lower quartiles (box limits), min to max range. f The Kaplan–Meier survival curve for IFIT3. Source data are provided as a Source Data file.

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