Fig. 9: Schematic illustration of PMO in counteracting ferroptosis and alleviating liver injury. | Nature Communications

Fig. 9: Schematic illustration of PMO in counteracting ferroptosis and alleviating liver injury.

From: Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury

Fig. 9: Schematic illustration of PMO in counteracting ferroptosis and alleviating liver injury.The alternative text for this image may have been generated using AI.

PMO can mimic the activities of multiple antioxidant enzymes and scavenge broad-spectrum ROS. After being absorbed mainly through macropinocytosis, PMO largely reside in lysosomes, where PMO scavenge ROS, inhibit ferritinophagy-mediated iron release and preserve mTOR activation, leading to the robust inhibition of ferroptosis. The intravenously injected PMO are mainly enriched in the liver and can alleviate DILI (drug-induced liver injury) and LIRI (liver ischemia/reperfusion injury).

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