Fig. 2: Individual-level VRC01 serum concentrations and decay over time.
a Observed VRC01 serum concentration (log10-scale) over time in PrEP (n = 24), and non-PrEP (n = 24) users by VRC01 dose group. Serum samples were collected 4 weeks (open triangles) and 8 weeks after each infusion (crosses), as well as 5 days after the 2nd infusion at the Day 61 visit (open circles); last study visit with VRC01 serum concentrations measured was at the Week 88 visit (marked with x). All infusion visits were subject to a visit window between −7 and 49 days; all mid-points between infusion visits were subject to a visit window between −7 and 7 days; Day 61 visit was subject to a visit window between −1 and 3 days. b Distributions of VRC01 serum concentrations at Day 61, geometric mean concentrations across all attended 4-week and 8-week postinfusion visits, and concentrations at Week 88 in PrEP (n = 24) and non-PrEP (n = 24) users by VRC01 dose group. The horizontal bars are the geometric mean of concentrations across PrEP (red) and non-PrEP (blue) users. c Distributions of decay slopes between 4-week and 8-week post-infusion visits in PrEP users (red) (n = 24) and non-PrEP (blue) users (n = 24) by infusion number. The decay slope after each infusion was calculated for each individual via dividing the difference in VRC01 serum concentrations (log10-scale) between the 4-week and 8-week postinfusion visits by the actual number of days between the two visits. The mid-line of the box denotes the median and the ends of the box denote the 25th and 75th percentiles. The whiskers at the top and bottom of the box extend to the most extreme data points that are no more than 1.5 times the interquartile range (i.e., height of the box) or if no value meets this criterion, to the data extremes.
