Fig. 7: Individual-level PK parameter estimates. | Nature Communications

Fig. 7: Individual-level PK parameter estimates.

From: Adults on pre-exposure prophylaxis (tenofovir-emtricitabine) have faster clearance of anti-HIV monoclonal antibody VRC01

Fig. 7: Individual-level PK parameter estimates.

a clearance (CL) (L/day); b Vp (L); c Distribution half-life (day); d Elimination half-life (day); and e area under the curve (AUC) (day/mL) vs. median-scaled intestinal epithelial permeability marker I-FABP levels (pg/mL) based on the popPK model restricted to VRC01 serum concentration data collected after the “first visit on PrEP” timepoint. Data from 23 PrEP users and 23 non-PrEP users were included due to missing I-FABP level from one PrEP user and one non-PrEP user. Spearman correlation coefficients (r) and p-values for testing a non-zero correlation are included. A linear regression line with pointwise 95% confidence interval band (shaded area) is also included.

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