Fig. 4: Gene prioritization for kidney stone disease. | Nature Communications

Fig. 4: Gene prioritization for kidney stone disease.

From: Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture

Fig. 4: Gene prioritization for kidney stone disease.The alternative text for this image may have been generated using AI.

a The prioritized genes identified by kidney-specific eQTL and meQTL mapping and TWAS. b Regional plots of GWAS signals at 1q32.1. c Regional plots of GWAS signals at 17q21.31. The lead variants are indicated by the purple diamond and black labeled, while the neighboring variants are colored based on their LD with the lead variant in European samples from 1000 Genomes Project. Gray color indicates LD information not available in the 1000 Genomes Project. The snATAC-seq chromatin accessible regions of human kidney are labeled in red. d The prioritized genes at 1q32.1. e The prioritized genes at 17q21.31. The asterisk indicates the GWAS signals are colocalized with the kidney-specific eQTL at the TWAS prioritized genes.

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