Fig. 9: SLC35D3 promotes white adipose tissue browning to ameliorate obesity via NOTCH signaling. | Nature Communications

Fig. 9: SLC35D3 promotes white adipose tissue browning to ameliorate obesity via NOTCH signaling.

From: SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling

Fig. 9: SLC35D3 promotes white adipose tissue browning to ameliorate obesity via NOTCH signaling.The alternative text for this image may have been generated using AI.

SLC35D3 regulates obesity by interacting with the extracellular domain (ECD) of NOTCH1, which promotes NOTCH1 accumulation in the endoplasmic reticulum (ER) and inhibits NOTCH1 transport to the cell membrane, ultimately inhibiting NOTCH1 signaling. IngWAT, inguinal white adipose tissue.

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