Fig. 8: Application of MAH-based Pd precatalysts in reaction discovery and optimization for the asymmetric allylation of hydantoin derivative 22. | Nature Communications

Fig. 8: Application of MAH-based Pd precatalysts in reaction discovery and optimization for the asymmetric allylation of hydantoin derivative 22.

From: Chiral, air stable, and reliable Pd(0) precatalysts applicable to asymmetric allylic alkylation chemistry

Fig. 8: Application of MAH-based Pd precatalysts in reaction discovery and optimization for the asymmetric allylation of hydantoin derivative 22.The alternative text for this image may have been generated using AI.

At low Pd loading. A Ligand selection achieved using in situ catalyst formation with DMPDAB–Pd–MAH. B 24 reaction solvent/base array using precatalyst 1. C Optimization of continuous variable setpoints to maximize yield, enantioselectivity, and catalyst TON. D Gram-scale synthesis of 23 using optimized conditions.

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