Fig. 3: Relative distance algorithm identifies more dynamic complexes in TPCA and Slim-TPCA. | Nature Communications

Fig. 3: Relative distance algorithm identifies more dynamic complexes in TPCA and Slim-TPCA.

From: Improved in situ characterization of protein complex dynamics at scale with thermal proximity co-aggregation

Fig. 3: Relative distance algorithm identifies more dynamic complexes in TPCA and Slim-TPCA.

a, b Correlation of the TPCA Modulation Signature of CORUM complexes obtained using the relative distance algorithm and the absolute distance algorithm for 10 and 4 temperature points, respectively (n = 821 complexes). c, d Comparison of the dynamic complexes identified by the relative distance algorithm with the absolute distance algorithm at 10 and 4 temperatures, respectively. e Number and functional class of convergent protein complexes identified with different algorithms. Compared to the absolute distance algorithm, the relative distance algorithm identifies more dynamic complexes associated with cell cycle, according to the annotation in the CORUM database. f, g Curves of subunits in Complex 2792 under DMSO and MTX, with 10 temperature points and 4 temperature points, respectively. Source data are provided as a Source Data file.

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