Fig. 5: Application of optimized TPCA profiling to K562 cells under glucose deprivation. | Nature Communications

Fig. 5: Application of optimized TPCA profiling to K562 cells under glucose deprivation.

From: Improved in situ characterization of protein complex dynamics at scale with thermal proximity co-aggregation

Fig. 5: Application of optimized TPCA profiling to K562 cells under glucose deprivation.

a Schema of samples collected. K562 are deprived of glucose in culture medium and harvested at different time point for heating at 3 temperatures for TPCA profiling. b Numbers of CORUM-annotated protein complexes detected at different time point with convergent and divergent TPCA signature. c Major functional classes of proteins in divergent protein complexes. d TPCA profile of selected convergent and divergent protein complexes at different time point of glucose deprivation. Source data are provided as a Source Data file.

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