Fig. 7: Model of the proposed mechanism by which Gas5 influences synaptic activity and the formation of fear extinction memory. | Nature Communications

Fig. 7: Model of the proposed mechanism by which Gas5 influences synaptic activity and the formation of fear extinction memory.

From: Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

Fig. 7: Model of the proposed mechanism by which Gas5 influences synaptic activity and the formation of fear extinction memory.

Extinction learning leads to the accumulation of the Gas5 variant in the synaptic compartment, which then sequesters CAPRIN1 and G3BP2 containing RNA granules away from clustering, leading to an increase in local protein synthesis and tighter control over synaptic plasticity.

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