Fig. 1: Methionine restriction decreases its metabolites and extends female lifespan.
From: Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila
a, b Lifespans of female Canton-S (a) and wDah (b) flies fed with or without a methionine-restricted diet. Sample sizes (n) are shown in the figure. For the statistics, a log-rank test was used. c, d Fecundity of Canton-S (c) and wDah (d) flies fed with or without a methionine-restricted diet. n = 10. For the statistics, a two-tailed Student’s t test was used. e, f Survivability of female Canton-S (e) or wDah (f) flies upon complete starvation after feeding with or without a methionine-restricted diet for one week. Sample sizes (n) are shown in the figure. g H2O2 resistance of female Canton-S flies after feeding with or without a methionine-restricted diet for one week. Sample sizes (n) are shown in the figure. h Methionine metabolic pathway and its oxidation to methionine sulfoxide. i–m Quantification of methionine metabolites and the oxidative product upon methionine restriction for one week. n = 6. For the statistics, a two-tailed Student’s t test was used. For all graphs, the mean and SEM are shown. Data points indicate biological replicates. Source data are provided as a Source Data file.
