Fig. 4: Time-course transcriptomic responses to methionine restriction.
From: Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila
a–c Numbers (a) and Venn diagrams (b, c) of differentially expressed genes of the 3’ RNAseq results from the intestines of female flies upon acute (six hours) or chronic (two or four weeks) methionine restriction. d List of commonly upregulated genes in the female intestines after two and four weeks of methionine restriction. e Commonly downregulated genes in the female intestines after six hours and four weeks of methionine restriction. f Commonly downregulated genes in the female intestines after two and four weeks of methionine restriction. g Possible transcription factors related to the transcriptional responses upon methionine restriction analysed by i-cisTarget. h, i Lists of commonly upregulated (h) and downregulated (i) genes in the female abdomens upon four weeks of methionine restriction. For the statistics, Wald test was used with DESeq2 (d–f, h, i). Log2 FC, Log2 Fold Change, padj, adjusted p-value.
