Fig. 6: Loss of MsrA abolishes lifespan extension by early adult methionine restriction.
From: Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila
a The gene structure of MsrA and the insertion site of the p-element in the MsrAEY05753 mutant. b Lifespans of female flies of wDah and MsrAEY05753 fed with or without a methionine-restricted diet in early life. Sample sizes (n) are shown in the figure. For the statistics, a log-rank test was used. c–g Quantification of methionine metabolites and the oxidative product in female wDah or MsrAEY05753 flies upon methionine restriction. n = 6. For the statistics, one-way ANOVA with Holm-Å Ãdák’s multiple comparison test was used. For all graphs, the mean and SEM are shown. Data points indicate biological replicates. Source data are provided as a Source Data file.
