Fig. 2: Contribution of immune cell sub-populations to aCD20-mediated differences in cell composition at different timepoints depicted by principal components analysis (PCA). | Nature Communications

Fig. 2: Contribution of immune cell sub-populations to aCD20-mediated differences in cell composition at different timepoints depicted by principal components analysis (PCA).

From: Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases

Fig. 2: Contribution of immune cell sub-populations to aCD20-mediated differences in cell composition at different timepoints depicted by principal components analysis (PCA).The alternative text for this image may have been generated using AI.

A–H PCA for the 18 identified immune clusters in untreated and aCD20-treated MS A, C, E & G and NMOSD patients B, D, F & H at T0 A, B, T1 C, D, T2 E, F and T3 G, H. Each point represents one sample’s scores on the first 2 dimensions (Dim1 and Dim2). Each vector (arrow) shows the loadings of each cell cluster on the first 2 principal components. Gray scale indicates the contribution value of variables to Dim1 and Dim2. The red dashed line on the graph indicates the expected average contribution. The graph shows top variables (with a contribution larger than average) contributing to Dim1.

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