Fig. 3: Different mechanistic scenarios involving Mb-cIII in Mb-catalyzed cyclopropanation with BDK.
From: Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone
IPC iron-porphyrin carbene complex. a Mechanism featuring Mb-cIII as dead-end byproduct. b Mechanism with Mb-cIII as off-cycle intermediate capable of re-generating IPC. c Mechanism featuring Mb-cIII formation from IPC as an alternative pathway competing with olefin cyclopropanation by IPC. d Mechanism with Mb-cIII as catalytically competent intermediate capable of mediating olefin cyclopropanation.
