Fig. 4: Proteins with the most important discriminative value (top 1%) and their associations with each endpoint.
From: Plasma proteomic profiles predict individual future health risk
a Stacked bar chart of standardized SHAP values from ProNNet across 14 disease categories and all-cause mortality, numbers on top of the bars indicate how many disease categories in which this protein showed the predominant discriminatory significance. We highlighted 34 proteins that exhibited the most important discriminatory value in two or more disease categories. b Associations between proteins are shown in (a) and 45 endpoints. The color of cells indicates the effect size (HR) between each protein and incident endpoint. HR was derived based on normalized proteins fitted using Cox proportional hazard models adjusted with age and sex. Asterisks in cells represent significant associations after correction for multiple comparison testing (p-value < 6.84 × 10−6 = 0.01/1461, p-value was derived corresponding to a two-sided test). Source data are provided as a Source Data file. HR hazard ratio, SHAP SHapley Additive exPlanations.
