Fig. 2: TSLP receptor signaling promotes non-healing L. major infection. | Nature Communications

Fig. 2: TSLP receptor signaling promotes non-healing L. major infection.

From: Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis

Fig. 2

a Lesion development and pathology score over the course of infection with 103 LmSd metacyclic promastigotes, and (b) Parasite burdens were quantified at 12 weeks p.i. in the ear dermis of WT (n = 10), Il25−/− (n = 10), Il33−/− (n = 6), and Tslpr−/− (n = 10) mice. c The absolute numbers of indicated cells and (d) intracellular staining for IL5/IL13 expressions in ILC2s from ear isolates of WT and Tslpr−/− mice were compared at 12 days p.i. with 2 × 105 LmSd (n = 10). Values represent mean ± standard deviation. *P < 0.05, **P < 0.01, and ***P < 0.001 by one-way ANOVA with Dunn’s posttest compared with Tslpr−/− (a) and two-sided non-parametric Mann-Whitney test (b–d). Data are representative of two independent experiments (a–d). Source data are provided as a Source Data file.

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