Fig. 7: TSLP from dermal TRMs promotes non-healing L. major infection.
a Quantification of Tslp expression from the sorted MRhigh dermal TRMs of WT, Ccl24-cre: Tslpf/+, Ccl24-cre: Tslpf/f animals at 12 days p.i. with 2 × 105 parasites (n = 4). b The absolute numbers of indicated cells and (c) % IL-5+ or IL-13+ ILC2s recovered from ears of WT, Ccl24-cre: Tslpf/+, Ccl24-cre: Tslpf/f animals were measured at 12 days p.i. with 2 × 105 LmSd (n = 6). d Lesion development and pathology scores over the course of infection with 103 LmSd metacyclic promastigotes in the ear dermis of WT (n = 10), Ccl24-cre: Tslpf/+ (n = 6), Ccl24-cre: Tslpf/f animals (n = 18). e Parasite burdens were quantified at 9 weeks p.i. in the ear dermis of WT (n = 10), Ccl24-cre: Tslpf/+ (n = 6), Ccl24-cre: Tslpf/f animals (n = 8). Values represent mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 by one-way ANOVA with Dunn’s post-test compared to Ccl24-cre: Tslpf/f animals (a–e). Data are representative of two independent experiments (a–e). Source data are provided as a Source Data file.
