Fig. 7: Schematic illustration for the regulation of hepatic Mn homeostasis and ammonia disposal by fructose overconsumption. | Nature Communications

Fig. 7: Schematic illustration for the regulation of hepatic Mn homeostasis and ammonia disposal by fructose overconsumption.

From: Fructose overconsumption impairs hepatic manganese homeostasis and ammonia disposal

Fig. 7

The Mn exporter Slc30a10 is a target of ChREBP in liver. In the absence of ChREBP, Slc30a10 expression is reduced, and intracellular Mn contents as well as arginase activity are increased. Dietary fructose activates the transcription of Slc30a10 through ChREBP, thereby promoting Mn efflux and reducing Mn content. ARG, arginase. The figure was created with Biorender.com.

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